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LUNG ALERT
Mechanical ventilation may damage organs other than the lungs
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  1. M K Johnson
  1. Glasgow Royal Infirmary, Glasgow, UK johnson7@which.net

https://doi.org/10.1136/thorax.58.7.612

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    ▴ Imai Y, Parodo J, Kajiwaka O, et al. Injurious mechanical ventilation and end-organ epithelial cell apoptosis and organ dysfunction in an experimental model of acute respiratory distress syndrome. JAMA2003;289:2104–12
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    In this laboratory study, acute respiratory distress syndrome was induced by acid aspiration in 24 rabbits which were then randomised to injurious (tidal volume 15–17 ml/kg, PEEP 0–3 cm H2O) or non-injurious ventilation (tidal volume 5–7 ml/kg, PEEP 9–12 cm …

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