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Thorax 58:306-310 doi:10.1136/thorax.58.4.306
  • Asthma

Intravenous salbutamol bolus compared with an aminophylline infusion in children with severe asthma: a randomised controlled trial

Table 2

Progress of study subjects

Item Salbutamol (n=18) Aminophylline (n=26) Difference (95% CI) p value*
Values for the sulbutamol and aminophylline groups are presented with standard errors (SE).
*Comparison of subjects in each group using unpaired t test (change in ASS, duration of oxygen and infusion, and time to discharge) or Wilcoxon rank sum test (ASS at 2 hours).
All subjects included in the intention to treat analysis.
Asthma severity score (ASS) at 2 hours 6 (0.37) 6.5 (0.33) 0.5 (–) 0.93
Change in ASS from time 0 to 2 hours –1.11 (0.39) –1.19 (0.25) –0.08 (–0.97 to 0.80) 0.85
Duration of oxygen therapy (hours) 17.8 (8.9) 7.0 (6.1) 2.56 times longer (0.92 to 7.18) 0.07
Duration of infusion (hours) 32.2 (3.2) 27.8 (0.85) –4.4 (–6.2 to 14.8) 0.41
Time to discharge (hours) 85.4 (13.2) 57.3 (8.5) 1.49 times longer (1.06 to 2.10) 0.02

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