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Thorax 58:163-174 doi:10.1136/thorax.58.2.163
  • Occasional review

Pharmacotherapy and airway remodelling in asthma?

  1. P A Beckett,
  2. P H Howarth
  1. Respiratory Cell Molecular Biology Division, Southampton General Hospital, Southampton SO16 6YD, UK
  1. Correspondence to:
    Dr P A Beckett, Respiratory Cell Molecular Biology Division, Level D, Centre Block, Southampton General Hospital, Southampton SO16 6YD, UK; pab{at}soton.ac.uk

    Abstract

    Over the last few decades attention has largely focused on airway inflammation in asthma, but more recently it has been appreciated that there are important structural airway changes which have been grouped together under the term “airway remodelling”. It is only now that questions have been asked about the impact of treatment on these structural changes. This review examines the nature of these structural airway changes, the mechanisms of their generation, their potential consequences, and what is known about the ability of anti-asthma treatments to modulate these changes.