Table 1
IL-10, TNF-α and IL-6 SNP distribution in patients with CAP grouped according to systemic inflammatory response syndrome (SIRS) score
| Illness severity group | ||||
|---|---|---|---|---|
| SNP | Non-SIRS | SIRS 2 | SIRS 3 | SIRS 4 |
| SNP=single nucleotide polymorphism. | ||||
| *p<0.05, non-parametric test for trend; **p=0.02, non-parametric test for trend. | ||||
| IL-10 GG* | 5 (26%) | 3 (18%) | 12 (36%) | 12 (50%) |
| IL-10 GA | 7 (37%) | 10 (59%) | 12 (36%) | 9 (38%) |
| IL-10 AA | 7 (37%) | 4 (24%) | 9 (27%) | 3 (13%) |
| IL-10 G allele** | 17 (45%) | 16 (47%) | 36 (55%) | 33 (69%) |
| TNF-α GG | 10 (53%) | 7 (41%) | 20 (61%) | 14 (58%) |
| TNF-α GA | 9 (47%) | 9 (53%) | 11 (33%) | 10 (42%) |
| TNF-α AA | 0 (0) | 1 (6%) | 2 (6%) | 0 (0) |
| TNF-α A allele | 9 (24%) | 11 (32%) | 15 (23%) | 10 (21%) |
| IL-6 GG | 3 (16%) | 6 (35%) | 9 (27%) | 7 (29%) |
| IL-6 GC | 12 (63%) | 8 (47%) | 19 (58%) | 11 (46%) |
| IL-6 CC | 4 (21%) | 3 (18%) | 5 (15%) | 6 (25%) |
| IL-6 G allele | 18 (47%) | 20 (59%) | 37 (56%) | 25 (52%) |
