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Thorax 58:1027-1030 doi:10.1136/thorax.58.12.1027
  • α1-antitrypsin deficiency

Correlation between annual change in health status and computer tomography derived lung density in subjects with α1-antitrypsin deficiency

Table 3

Correlation between St George Respiratory Questionnaire (SGRQ) and both lung function and lung density

Baseline FEV1 Baseline Kco Baseline Perc15 Baseline RA-950
R p value R p value R p value R p value
*Correlation significant at 0.05 level (two tailed).
R = Spearman correlation coefficient; Δ = change in 30 months; Perc15 = 15th percentile point; RA-950 = relative area below −950 HU; FEV1 = forced expiratory volume in 1 second; Kco = carbon monoxide transfer coefficient.
Baseline SGRQ –0.61* 0.002 –0.54* 0.011 –0.47* 0.028 0.50* 0.018
Change in SGRQ Δ FEV1 Δ Kco Δ Perc15 Δ RA-950
Healthy (n = 6) –0.20 0.70 0.23 0.65 –0.41 0.42 0.06 0.91
Emphysema (n = 16) –0.22 0.42 –0.26 0.34 –0.74* 0.001 0.67* 0.004
Total group (n = 22) –0.28 0.21 –0.18 0.44 –0.56* 0.007 0.60* 0.003

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