Eosinophil activation and preschool viral wheeze
- Leicester Children’s Asthma Centre, Institute for Lung Health, University of Leicester, PO Box 65, Leicester LE2 7LX, UK
- Correspondence to:
Dr J Grigg
Leicester Children’s Asthma Centre, Institute for Lung Health, University of Leicester, Leicester LE2 7LX, UK; jg33le.ac.uk
- Accepted 3 June 2003
- Revised 28 March 2003
Abstract
Background: A study was undertaken to ascertain whether systemic eosinophil activation is associated with preschool viral wheeze (PVW).
Methods: Urinary eosinophil protein X (uEPX) and serum total IgE (IgE) levels were measured in children admitted to hospital with PVW, and uEPX was measured 6 weeks after discharge. Two years after admission, current wheeze in children aged ≥5 years was determined by questionnaire. Controls were recruited from children undergoing elective surgery (normal controls) and from those with skin prick test reactivity to foods (atopic controls).
Results: There was no difference in uEPX levels between normal controls (n=15) and atopic controls (n=8). uEPX levels were increased in children with acute PVW (n=84; p<0.001 v normal controls, p<0.01 v atopic controls) and fell on convalescence (n=20, 95% CI −217 to −31 µg/mmol creatinine, p<0.05). In children with acute PVW there was no association between uEPX and serum IgE levels or markers of clinical severity. Respiratory questionnaires were returned for 25/55 eligible children. There was no difference in uEPX level during acute PVW when stratified by “current wheeze” (n=18) or “no wheeze” (n=7) 2 years later.
Conclusions: Systemic eosinophil activation is associated with PVW but is not associated with serum IgE, clinical severity, or persistence of wheeze into the early school age period.
