Article Text
Abstract
Background: Primary ciliary dyskinesia (PCD) is associated with chronic airway inflammation resulting in bronchiectasis.
Methods: The levels of exhaled nitric oxide (eNO), carbon monoxide (eCO) and nasal NO (nNO) from bronchiectatic patients with PCD (n=14) were compared with those from patients with non-PCD bronchiectasis without (n=31) and with cystic fibrosis (CF) (n=20) and from normal subjects (n=37) to assess the clinical usefulness of these measurements in discriminating between PCD and other causes of bronchiectasis.
Results: Exhaled NO levels were lower in patients with PCD than in patients with non-PCD non-CF bronchiectasis or healthy subjects (median (range) 2.1 (1.3–3.5) ppb v 8.7 (4.5–26.0) ppb, p<0.001; 6.7 (2.6–11.9) ppb, p<0.001, respectively) but not lower than bronchiectatic patients with CF (3.0 (1.5–7.5) ppb, p>0.05). Nasal levels of nNO were significantly lower in PCD patients than in any other subjects (PCD: 54.5 (5.0–269) ppb, non-PCD bronchiectasis without CF: 680 (310–1000) ppb, non-PCD bronchiectasis with CF: 343 (30–997) ppb, control: 663 (322–1343) ppb). In contrast, eCO levels were higher in all patient groups than in control subjects (PCD: 4.5 (3.0–24.0) ppm, p<0.01, other bronchiectasis without CF: 5.0 (3.0–15.0) ppm, p<0.001; CF: 5.3 (2.0–23.0) ppm, p<0.001 v 3.0 (0.5–5.0) ppm). Low values in both eNO and nNO readings (<2.4 ppb and <187 ppb, respectively) identified PCD patients from other bronchiectatic patients with a specificity of 98% and a positive predictive value of 92%.
Conclusion: The simultaneous measurement of eNO and nNO is a useful screening tool for PCD.
- exhaled nitric oxide
- exhaled carbon monoxide
- bronchiectasis
- primary ciliary dyskinesia
- cystic fibrosis
- nasal nitric oxide
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Supplementary materials
Publisher's Correction
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- [View PDF] - Figure 1 Exhaled nitric oxide, nasal nitric oxide, and exhaled carbon monoxide concentrations in normal subjects, patients with primary ciliary dyskinesia (PCD) with documented bronchiectasis, and patients with non-PCD bronchiectasis with and without cystic fibrosis (CF). The Kruskal-Wallis test showed significant differences between mediator levels (p <_0.0001.-- end="end" desc="desc" dc1="dc1" _1="_1" _--="_--">
Footnotes
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This study was supported by the Hungarian National Scientific Research Foundation (OTKA-T030340) and by a joint grant of the British Council and the Hungarian OMFB (grant number: GB-31/98).
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