Thorax 57:540-546 doi:10.1136/thorax.57.6.540
  • Review series

The pulmonary physician in critical care • 6: The pathogenesis of ALI/ARDS

  1. G J Bellingan
  1. Correspondence to:
    G J Bellingan, Department of Intensive Care Medicine, University College Hospitals, Centre for Respiratory Research, Rayne Institute, London WC1E 6JJ;


    An understanding of the pathogenesis of ARDS is essential for choosing management strategies and developing new treatments. The key mediators involved in the inflammatory and fibroproliferative responses are reviewed and the mechanisms which regulate these responses are highlighted.