Some asthma linkage loci (associated asthma candidate genes) and obesity candidate genes in the same regions
| Asthma consensus loci | Obesity candidate gene loci |
|---|---|
| 5q23-31 (IL-4, IL-5, IL-9, GMCSF, β2AR, CD14) | 5q22.3 (ISL1) |
| 5q31 (GRL) | |
| 5q32-34 (β2AR) | |
| 6p21.3-p23 (HLA, TNFα) | 6p21.2-p21.1 (GLO1) |
| 6p21.3 (BF) | |
| 6p21.3 (TNFα) | |
| 11q13 (FCERB, CC16) | 11q13 (UCP2) |
| 11q13 (UCP3) | |
| 12q14-q24.2 (IFNγ, LTA4H, NOS1) | 12q13 (STAT6) |
| 12q22-q24.1 (IGF1) | |
| 12q24 (CD36L1) |
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IL = interleukin; GMCSF = granulocyte monocyte colony stimulating factor; β2AR = β2 adrenergic receptor; ISL1 = islet cell 1; GRL = glucocorticoid receptor; HLA = human leucocyte antigen; TNFα = tumour necrosis factor alpha; GLO-1 = glyoxalase; BF = B factor, properdin; FCERB = IgE fc receptor beta; CC16 = Clara cell 16; UCP = uncoupling protein; IFNγ = interferon gamma; LTA4H = leukotriene A4 hydroxylase, NOS1 = neuronal nitric oxide synthase; STAT6 = signal transducer and activator of transcription ; IGF = insulin like growth factor; CD36L1 = CD36 antigen-like.
