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Thorax 56:567-569 doi:10.1136/thorax.56.7.567
  • Short paper

Cardiovascular side effects of inhaled salbutamol in hypoxic asthmatic patients

Table 1

Mean (SD) values (n=8) for mean arterial pressure (MAP), heart rate (HR), QTc interval, forearm vascular resistance (FVR), and serum potassium levels (K+) at baseline (t=0) and at the end of the experiment (t=60)

MAP (mm Hg) HR (bpm) QTc (ms) FVR (mmHg/%FBF) K+(mmol/l)
t=0 t=60 t=0 t=60 t=0 t=60 t=0 t=60 t=0 t=60
NP 81.7 (6.9) 82.4 (9.3) 69.0 (8.1) 64.8 (11.5) 390 (20) 395 (12) 29.3 (14.2) 28.3 (13.6) 4.22 (0.14) 4.10 (0.37)
HP 82.5 (7.2) 82.5 (7.8) 65.0 (9.4) 70.9 (10.9)1-160 389 (15) 397 (16) 26.2 (11.4) 23.9 (13.6) 3.99 (0.21) 4.01 (0.15)
NS 81.6 (8.1) 83.5 (7.9) 65.1 (8.4) 66.8 (13.3) 393 (14) 398 (12) 25.0 (7.4) 21.1 (8.3) 4.06 (0.28) 4.02 (0.35)
HS 81.8 (3.9) 82.9 (8.6) 62.4 (8.7) 76.3 (9.2)*** 384 (18) 409 (23)1-150 30.9 (9.5) 21.9 (8.9)1-160 4.08 (0.26) 3.89 (0.17)
p value 0.857  <0.001 0.037 0.034 0.495
  • NP = normoxia + placebo; HP = hypoxia + placebo; NS = normoxia + salbutamol; HS = hypoxia + salbutamol.

  • Significant differences from NP as percentage change from t=0 value:

  • 1-150 p<0.05;

  • 1-160 p<0.01;*** p<0.001.

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