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Thorax 56:198-204 doi:10.1136/thorax.56.3.198
  • Original article

Medical treatment for reflux oesophagitis does not consistently improve asthma control: a systematic review

Table 3

Summary of results of gastro-oesophageal reflux treatment on asthma outcomes

Study FEV1 Morning PEF Evening PEF AHR Asthma symptoms Nocturnal symptoms Asthma medications
Ekstrom19 NE NE NE NE NE + +
Ford20 NA NE NE NA NE NE NE
Goodall21 NE NE + NA NE + NE
Gustafsson22 NE NA NA NE NE NE NA
Kjellen23 NE NA NA NA + NA +
Larrain24(cimetidine) + NA NA NA + NA +
Larrain24(surgery) NE NA NA NA + NA +
Meier25 + NA NA NA NE NA NE
Nagel26 NA NE NE NA NE NA NE
Teichtahl27 NE NE + NE NE NA NA
Boeree28 NE NE NE NE NE NE NA
Levin29 NE + NE NA + NA NA
Kiljander30 NE NE NA NA NE + NE
  • + = significant treatment effect (p<0.05); NA = data not available; NE = no significant treatment effect; FEV1 = forced expiratory flow in one second; PEF = peak expiratory flow; AHR = airway hyperresponsiveness.

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