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Dr Robinson's review of cystic fibrosis (CF) touches on the use of continuous anti-staphylococcal antibiotic prophylaxis.1 Dr Robinson reiterates the oft repeated assertion that there is an association between the use of prophylactic antibiotics and the early acquisition of pulmonary infection withPseudomonas aeruginosa in patients with CF. This putative association has entered CF folklore but is not supported by any published evidence. The paper cited by Robinson describes a pilot study of cephalexin which lasted 2 months.2 A subsequent multicentre randomised placebo controlled trial of cephalexin, commenced in children under 2 years, has been undertaken and its methodology described.3 However, no results have so far appeared in the published literature.
We have recently published an updated systematic review of randomised controlled …