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Thorax 56:42-47 doi:10.1136/thorax.56.1.42
  • Original article

Methacholine responsiveness in infants assessed with low frequency forced oscillation and forced expiration techniques

Table 3

Threshold concentration (TC) for the infant lung function parameters

Patient no TC FEV0.5 TC Raw TC Iaw TC G TC H TC η
1 1 0.25
2 0.25 0.25 0.25
3 1 1 1 1
4 4 2 2 2 4
5 0.5 0.5 0.25 0.25
6 2 1 1 0.25 0.25
7 0.25 0.5 0.5 0.5 0.5
8 0.25 0.25 0.25 0.25 0.25
9 Aw 2 2
10 4 4 4
11 1 1 0.25 1
12 2 0.5 0.5
13 2 0.5 1
14 2 4 0.5 8 8
15 4
16 2 0.25 0.25 0.25 1
17 0.5 0.5
Median (25% to 75% CI) 1.5 (0.5 to 2) 0.75 (0.25 to 1) 0.5 (0.25 to 1) 0.375 (0.25 to 2) 0.5 (0.375 to 0.75) 1 (0.5 to 4)
  • Raw = airway resistance; Iaw = airway inertance; G = tissue damping; H = tissue elastance; η = tissue hysteresivity; – = parameters not reaching threshold concentration.

  • One infant woke spontaneously before the end of the test (patient 9).

  • Threshold concentrations for each parameter are expressed in mg/ml methacholine. There were no significant differences between the threshold concentrations in any lung function parameter.

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