Table 1
De novo production of sulfidoleukotrienes (SLT) in patients with positive and negative oral provocation test (OPT) to aspirin
| SLT (pg/ml) | ||
|---|---|---|
| OPT positive1-150 | OPT negative1-150 | |
| C5a (10–7 M) | n = 18 | n = 66 |
| Mean | 692 | 117 |
| Median | 583 | 79 |
| Min–max | 45–2010 | 0–549 |
| p<0.0001 | ||
| PAF (10–5M) | n = 8 | n = 32 |
| Mean | 371 | 56 |
| Median | 300 | 45 |
| Min–max | 141–647 | 0–198 |
| p<0.0001 | ||
| fMLP (10–6 M) | n = 8 | n = 32 |
| Mean | 444 | 123 |
| Median | 582 | 84 |
| Min–max | 11–848 | 0–647 |
| p<0.01 | ||
-
PAF = platelet activating factor; fMLP = f-Met-Leu-Phe.
-
↵1-150 Randomly selected patients with a history of adverse skin reaction to aspirin.
