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Thorax 2000;55:805-806 doi:10.1136/thorax.55.9.805
  • Case Report

Churg-Strauss syndrome associated with montelukast therapy

  1. J M Tuggey,
  2. H S R Hosker
  1. Department of Respiratory Medicine, Airedale General Hospital, Keighley, West Yorkshire BD20 6TD, UK
  1. Dr H S R Hosker, Department of Respiratory Medicine, Airedale General Hospital, Keighley, West Yorkshire BD20 6TD, UK
  • Received 12 August 1999
  • Revision requested 15 October 1999
  • Revised 10 December 1999
  • Accepted 6 January 2000

Abstract

Churg-Strauss syndrome is a rare form of eosinophilic vasculitis associated with asthma. There have been several recent case reports of the condition in association with leukotriene antagonists and it has been speculated that the Churg-Strauss syndrome was unmasked when oral corticosteroids were withdrawn. We report a case of Churg-Strauss syndrome associated with montelukast therapy in an asthmatic patient in whom there had been no recent oral corticosteroid use. We believe that this is the first such reported case and would suggest that clinicians need to be vigilant in all patients who develop systemic symptoms when starting treatment with leukotriene antagonists.

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