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Thorax 55:633-634 doi:10.1136/thorax.55.8.633
  • Editorial

Respiratory antibiotic use and Clostridium difficile infection: is it the drugs or is it the doctors?

Table 1

Antibiotics and risk of C difficile infection

High risk Medium risk Low risk
Cephalosporins Ampicillin/amoxycillin Aminoglycosides
Clindamycin Co-trimoxazole Metronidazole
Macrolides
Tetracyclines
Anti-pseudomonal penicillins  ± β-lactamase inhibitor
Quinolones
Rifampicin
Vancomycin
  • These subdivisions may be prone to bias because of the relative frequency of use of agents and the complexity of interaction between antibiotic exposure, C difficile, and other factors.

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