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Thorax 55:603-613 doi:10.1136/thorax.55.7.603
  • Occasional review

Molecular mechanisms of glucocorticoid action: what is important?

Table 1

GRE and nGRE sites in glucocorticoid responsive genes

Site Position Reference
Consensus GRE GGT ACA NNN TGT TCT 10, 22
Tyrosine aminotransferase TGT ACA GGA TGT TCT –2509/–2495 10, 23
Metallothionein IIA GGT ACA CTG TGTCCT –262/–248 24
sgk AGGACA GAA TGT TCT –1 kb 25
Lysozyme TGA TCC CTC TGT TCT –65/–51 26
Osteocalcin (nGRE) GG T ATA AAC AGTGCT –32/–17 27
  • GRE = glucorticoid response elements; nGRE = negative GREs; N = any base.

  • Bases in bold conform to the consensus sequence.

  • The overlapping TATA box in the osteocalcin nGRE is underlined.

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