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Thorax 55:478-483 doi:10.1136/thorax.55.6.478
  • Original article

Effect of leukotriene receptor antagonist therapy on the risk of asthma exacerbations in patients with mild to moderate asthma: an integrated analysis of zafirlukast trials

Table 2

Integrated analysis comparing the number of patients who had asthma exacerbations according to three definitions among patients who received zafirlukast 20 mg twice daily or placebo

Exacerbations that: Zafirlukast
(n = 972)
Placebo
(n = 692)
Odds ratio 95% confidence interval p value p value
(Breslow-Day test)
Led to withdrawal 26 (2.7) 38 (5.5) 0.45 0.26 to 0.76 0.003 0.833
Required additional asthma treatment 33 (3.4) 53 (7.7) 0.47 0.30 to 0.74 0.001 0.477
Required oral steroid treatment 31 (3.2) 45 (6.5) 0.53 0.32 to 0.86 0.010 0.702
  • Values are no. (%).

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