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Thorax 55:970-977 doi:10.1136/thorax.55.11.970
  • Occasional review

Factors influencing airway inflammation in chronic obstructive pulmonary disease

Table 1

Airway inflammation at the start of an exacerbation in outpatients with COPD, with and without severe α1-antitrypsin (AAT) deficiency

Sputum measurements at start of the exacerbation compared with stable state COPD AAT deficiency AAT deficiency vs COPD at start of the exacerbation
Myeloperoxidase ↑ ↑ ↔
Elastase activity ↑ ↑ ↑
Interleukin 8 ↔ ↑ ↑
Leukotriene B4 ↑ ↑ ↑
Secretory leukoprotease inhibitor ↓ ↓ ↓
Sputum α1-antitrypsin ↑ ↑ ↓
Albumin leakage (serum → sputum) ↑ ↑ ↑

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