We have already reported a unique case of bronchiectasis with chronic colonisation by UK epidemic (ET12)Burkholderia cepacia in a previously well woman which developed following an acute infection acquired from her two B cepacia colonised children with cystic fibrosis.1 This has intermediate sensitivity to only co-trimoxazole and ceftazidime and, despite several intravenous courses of these antibiotics, the patient has remained chronically colonised for more than four years. We have therefore looked for other antibiotics which may have action against this multidrug resistant pathogen. Taurolidine acts by disrupting the cell wall, diminishing bacterial adherence, and neutralising toxins.2 It has good in vitro anti-B cepacia activity (MIC 0.4 mg/ml) but is currently used as an antiseptic peritoneal lavage solution. We gave nebulised …