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Thorax 54:825-857 doi:10.1136/thx.54.9.825
  • Occasional review

Cytokines in asthma

Table 2

Chemoattractant effects of cytokines

Cytokine Eosinophil T cell Monocyte Neutrophil Others
IL-8 ± +++ “Primed” eosinophils
RANTES ++ Memory T cells + NK cells
MCP-1 + + ++ Basophils
MCP-3 + + + Dendritic cells
MCP-4 ++ + +
MIP-1α CD8+ cells ++ Dendritic cells, NK cells
Eotaxin +++ Basophils
STCP-1 Th2 cells
IL-2 ++
IL-4 Fibroblasts
IL-5 +
IL-15 +
IL-16 CD4+ T cells
IL-1β (+) ++
TNF-α ++
SCF Mast cells
  • IL = interleukin; MCP = monocyte chemoattractant protein; MIP = macrophage inflammatory protein; STCP = stimulated T cell chemoattractant protein; TNF = tumour necrosis; SCF = stem cell factor; NK = natural killer.

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