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Methacholine challenge and sputum induction
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  1. N RENÉE LABIRIS,
  2. F E HARGREAVE
  1. Asthma Research Group
  2. St Joseph’s Hospital and McMaster University
  3. 50 Charlton Avenue East, Hamilton, Ontario
  4. Canada L8N 4A6

https://doi.org/10.1136/thx.54.8.750e

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    Spanevello and colleagues claim that a methacholine inhalation challenge carried out one hour before sputum induction in patients with stable asthma does not significantly alter the cellular, eosinophil cationic protein (ECP), or albumin constituents of sputum.1 These results, if correct, are important for both clinical practice and clinical trials where information regarding airway hyperresponsiveness and inflammation is needed. Being able to perform a methacholine challenge and sputum induction on the same day would be convenient.

    Sixteen subjects with asthma were studied on …

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