Table 3
Changes in airway hyperresponsiveness, sputum eosinophil counts, and exhaled NO levels between steroid and placebo treatment groups
| Baseline - Week 4 | Week 4 - Washout | |
|---|---|---|
| Δ PC20 (mg/ml) | ||
| Steroid | 2.01 (1.60) | –1.75 (1.17) |
| Placebo | 0.19 (0.97) | 0.17 (1.15) |
| 95% CI | 0.483 to 2.034 | –2.066 to 0.583 |
| p value | 0.003 | 0.001 |
| Δ Sputum eosinophils (%) | ||
| Steroid | –2.46 (2.52) | 6.13 (6.37) |
| Placebo | 1.25 (6.30) | 2.95 (8.48) |
| 95% CI | –8.180 to 0.755 | –4.125 to 10.496 |
| p value | 0.098 | 0.37 |
| Δ Exhaled NO (ppb) | ||
| Steroid | –4.88 (3.13) | 3.65 (3.60) |
| Placebo | –1.50 (1.91) | 1.17 (3.27) |
| 95% CI | –5.571 to –1.175 | –0.600 to 5.566 |
| p value | 0.005 | 0.11 |
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Changes in PC20 expressed as geometric mean (SD) in doubling doses; changes in sputum eosinophil counts and exhaled NO levels expressed as mean (SD).
