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Thorax 54:150-160 doi:10.1136/thx.54.2.150
  • Occasional review

Treatment of adult respiratory distress syndrome: plea for rescue therapy of the alveolar epithelium

Table 1

Cytokines affecting growth and motility of lung alveolar epithelial cells

Promoters Growth Inhibitors Promoters Migration Inhibitors
EGF/TGFα86 88 + +
Acidic FGF86 88 + +
Basic FGF86 + +
FGF-7/KGF1-150 86 88 91 + +
IL-61-151 86 88 + + +
HGF86 88 + +
IL-21-152 88 135 + +
PDGF86 88 + +
TGFβ1-153 86 88 + + +
IFN-γ1-154 88 135 + + +
IGF-I and II88 87 + +

  • ↵1-150 KGF is pro-migratory for lung alveolar epithelial cells (LAEC) seeded on a fibronectin matrix but not on a neutral gelatin matrix.88 135

  • ↵1-151 IL-6 is equivocal factor of LAEC growth and migration but inhibits TGFα- and EGF-induced LAEC migration on gelatin matrix.88

  • ↵1-152 IL-2 is equivocal factor of LAEC migration but promoter when cells have been pre-exposed to IFN-γ.88

  • ↵1-153 Amongst TGFβ isoforms only TGFβ3 is pro-migratory for LAEC.88

  • ↵1-154 IFN-γ is equivocal factor of LAEC migration but inhibits TGFα- and EGF-induced LAEC migration on gelatin matrix.88

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