Successful treatment of post-influenza pseudomembranous necrotising bronchial aspergillosis with liposomal amphotericin, inhaled amphotericin B, gamma interferon and GM-CSF
- aDepartment of Anaesthesiology and Intensive Care, bDepartment of Infectious Diseases, cDivision of Microbiology, Department of Pathology, dRoyal Brisbane Hospital, Herston, Queensland, Australia 4029
- Dr RJ Boots.
- Received 30 July 1997
- Revision requested 25 November 1997
- Revised 3 February 1998
- Accepted 27 February 1998
A case of aspergillus tracheobronchitis following influenza A infection in an immunocompetent 35 year old woman is described that required prolonged mechanical ventilation for airways obstruction. Treatment included liposomal amphotericin, inhaled amphotericin, gamma interferon and GM-CSF. Liposomal amphotericin therapy was associated with reversible hepatosplenomegaly. Inhaled corticosteroids with continued antifungal therapy were used for the management of severe recurrent airway obstruction. After a prolonged course of treatment she survived with fixed airways obstruction unresponsive to corticosteroids.