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Thorax 54:65-69 doi:10.1136/thx.54.1.65
  • Review series

Genetics and pulmonary medicine: asthma

Table 3

Candidate genes for asthma and related phenotypes

Chromosome Candidate gene Association Known polymorphisms Reference
5 IL-4 IgE -590 C-T 21
IL-9 IgE M99T 22
β2AR IgE, BHR, treatment response, nocturnal asthma Codon 16, 27 23–29
6 HLA Specific IgE DR alleles 30
TNFα ?Asthma -308 20, 31
10 5-LO Asthma Promoter alleles 1–5 32
11 CC16 Asthma ? 33
FcεR1β Atopy, IgE, BHR Codon 181, 183, 237 34, 35
14 TCRα Specific IgE ? 36
16 IL-4α Atopy 576 R 37, 39

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