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Thorax 53:601-612 doi:10.1136/thx.53.7.601
  • Occasional review

Role of transcription factors in inflammatory lung diseases

Table 3

Inflammatory genes regulated by NF-κB

Cytokines
 Tumour necrosis factor α
Interleukin 1β
Interleukin 2
Interleukin 3
Interleukin 6
Interleukin 12
Growth factors
Granulocyte-macrophage colony-stimulating factor  (GM-CSF)
Granulocyte colony-stimulating factor (G-CSF)
Macrophage colony-stimulating factor (M-CSF)
Chemokines
Interleukin 8
Macrophage inflammatory protein 1 alpha (MIP-1-alpha)
Macrophage chemotactic protein 1 (MCP-1)
Gro-α, -β, and -γ
Eotaxin
RANTES
Inflammatory mediators
Inducible nitric oxide synthase (iNOS)
Inducible cyclo-oxygenase 2
5-lipoxygenase
Cytosolic phospholipase A2
C reactive protein
12-lipoxygenase
Adhesion molecules
Intercellular adhesion molecule 1 (ICAM-1)
Vascular cell adhesion molecule 1 (V-CAM-1)
E-selectin
Immunoreceptors
Interleukin-2 receptor (α-chain)
T-cell receptor (β-chain)
Platelet-activating factor receptor
CD11b and CD48
Proto-oncogenes
p53, c-myc, ras

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