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Thorax 53:594-600 doi:10.1136/thx.53.7.594
  • Occasional review

Iron metabolism in the lower respiratory tract

Table 4

Mean (SE) concentration of iron in alveolar macrophages (AM) in relation to occupation and lung diseases

μg/106AM nmol/106AM Perls (score 0–300)4-a
Controls 0.3 (0.0)7 5.9 (0.5)7 5.5 (1.6)15
0.3 (0.2)6 7.5 (0.6)17
12.8 (1.3)30
Asymptomatic smokers 0.6 (0.0)7 10.9 (2.2)7 21.7 (5.6)15
0.5 (0.4)6
Symptomatic smokers 1.4 (0.2)7 24.7 (4.3)7 25.8 (9.8)15
2.1 (0.9)6 27.6 (17.9)17
43.0 (7.7)30
Blast furnace workers 1.8 (1.5)6
Coke oven workers 1.1 (0.9)6
Welders 1.7 (0.6)6
Smoker patients with lung carcinoma 2.3 (2.7)6
Non-smoker patients with lung carcinoma 1.6 (3.0)6
Goodpasture syndrome 6.2 (1.5)6
  • Superscript numbers are reference numbers.

  • 4-a Perls staining evaluates haemosiderin content. Score was made on 100 AM (0 = absence of staining; 1 = weak (less than 25% cytoplasm stained); 2 = moderate (25–50% cytoplasm stained); 3 = intense (more than 50% stained).

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