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Thorax 53:269-273 doi:10.1136/thx.53.4.269
  • Original article

Effects of theophylline and ipratropium bromide on exercise performance in patients with stable chronic obstructive pulmonary disease

Table 2

Exercise data (mean differences from placebo with 95% confidence intervals)

Ipratropium bromide Theophylline Theophylline and ipratropium bromide
Wmax (Watts) 3.9 (−0.8 to 8.5) 7.1 (3.0 to 11.2)2-150 12.1 (6.3 to 18.0)2-150
o 2max (ml/min) 40 (7 to 73)2-150 77 (32 to 122)2-150 123 (62 to 183)2-150
co 2max (ml/min) 52 (0 to 104)2-150 69 (17 to 121)2-150 160 (93 to 228)2-150
emax (l/min) 2.2 (0.7 to 3.8)2-150 4.4 (2.4 to 6.4)2-150 8.5 (6.2 to 10.9)2-150
HRmax (beats/min) 1 (−2 to 5) 16 (10 to 22)2-150 19 (15 to 24)2-150
Sao 2at end of exercise (%) −1 (−2 to 1) 1 (−0 to 2) 0 (−1 to 2)
Borg score before load −0.2 (−0.5 to 0.1) −0.1 (−0.5 to 0.2) 0.1 (−0.4 to 0.5)
Borg score at Wmax −0.3 (−0.5 to 0.0) −0.1 (−0.3 to 0.2) 0.0 (−0.2 to 0.3)
  • Wmax = maximum work rate; V˙o 2max = maximum oxygen consumption; V˙co 2max = maximum carbon dioxide production; V˙emax = maximum minute ventilation; HRmax = maximum heart rate; Sao 2 = arterial oxygen saturation.

  • 2-150 p<0.05.

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