Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids

R G Stirling; S A Kharitonov; D Campbell; D S Robinson; S R Durham; K F Chung; P J Barnes

doi:10.1136/thx.53.12.1030

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Original article

Increase in exhaled nitric oxide levels in patients with difficult asthma and correlation with symptoms and disease severity despite treatment with oral and inhaled corticosteroids

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Online download statistics by month:

Online download statistics by month: February 1999 to March 2024

	Abstract	Full	Pdf
Feb 1999	0	2	1
Mar 1999	8	5	12
Apr 1999	2	16	14
May 1999	4	22	12
Jun 1999	3	16	23
Jul 1999	4	3	2
Aug 1999	4	5	3
Sep 1999	0	8	4
Oct 1999	3	6	5
Nov 1999	1	15	5
Dec 1999	1	0	4
Jan 2000	0	1	0
Feb 2000	0	4	5
Mar 2000	1	5	11
Apr 2000	0	6	7
May 2000	3	19	7
Jun 2000	0	9	6
Jul 2000	1	11	1
Aug 2000	2	6	2
Sep 2000	1	7	7
Oct 2000	1	10	10
Nov 2000	2	11	11
Dec 2000	5	6	9
Jan 2001	0	3	6
Feb 2001	1	8	10
Mar 2001	1	8	4
Apr 2001	3	8	2
May 2001	1	14	2
Jun 2001	5	12	4
Jul 2001	0	5	1
Aug 2001	2	8	3
Sep 2001	2	6	5
Oct 2001	5	9	4
Nov 2001	3	11	3
Dec 2001	1	10	1
Jan 2002	4	12	7
Feb 2002	1	9	7
Mar 2002	6	12	13
Apr 2002	2	11	6
May 2002	2	2	7
Jun 2002	0	2	4
Jul 2002	5	9	0
Aug 2002	2	9	8
Sep 2002	0	11	7
Oct 2002	1	19	9
Nov 2002	1	11	6
Dec 2002	4	13	9
Jan 2003	0	9	9
Feb 2003	2	4	7
Mar 2003	4	7	13
Apr 2003	2	6	7
May 2003	2	7	3
Jun 2003	0	14	11
Jul 2003	9	21	7
Aug 2003	9	25	13
Sep 2003	9	16	7
Oct 2003	10	20	6
Nov 2003	14	30	14
Dec 2003	15	18	8
Jan 2004	14	30	7
Feb 2004	6	23	4
Mar 2004	20	25	16
Apr 2004	16	33	15
May 2004	35	42	9
Jun 2004	39	43	6
Jul 2004	38	42	2
Aug 2004	44	58	13
Sep 2004	22	52	12
Oct 2004	12	38	13
Nov 2004	12	22	6
Dec 2004	7	18	8
Jan 2005	15	28	9
Feb 2005	13	26	9
Mar 2005	12	25	11
Apr 2005	3	11	7
May 2005	5	12	5
Jun 2005	5	46	13
Jul 2005	11	19	12
Aug 2005	15	11	12
Sep 2005	6	19	14
Oct 2005	11	18	7
Nov 2005	11	15	11
Dec 2005	8	9	2
Jan 2006	6	13	7
Feb 2006	8	9	9
Mar 2006	4	17	15
Apr 2006	1	13	9
May 2006	2	6	5
Jun 2006	0	7	4
Jul 2006	2	10	11
Aug 2006	3	9	4
Sep 2006	11	10	9
Oct 2006	9	16	13
Nov 2006	7	14	5
Dec 2006	7	17	3
Jan 2007	10	12	7
Feb 2007	5	16	9
Mar 2007	12	23	4
Apr 2007	25	7	7
May 2007	11	3	4
Jun 2007	15	5	9
Jul 2007	5	16	6
Aug 2007	15	7	7
Sep 2007	8	9	6
Oct 2007	29	14	4
Nov 2007	15	6	4
Dec 2007	13	1	2
Jan 2008	12	2	1
Feb 2008	10	4	4
Mar 2008	7	6	6
Apr 2008	7	4	6
May 2008	7	2	2
Jun 2008	5	3	3
Jul 2008	4	3	4
Aug 2008	13	8	9
Sep 2008	17	4	6
Oct 2008	9	3	4
Nov 2008	11	5	7
Dec 2008	9	6	5
Jan 2009	7	1	1
Feb 2009	4	1	8
Mar 2009	11	5	8
Apr 2009	6	7	8
May 2009	7	5	7
Jun 2009	3	3	5
Jul 2009	11	2	3
Aug 2009	9	2	4
Sep 2009	11	4	4
Oct 2009	15	0	0
Nov 2009	18	2	1
Dec 2009	8	1	2
Jan 2010	15	1	3
Feb 2010	8	1	2
Mar 2010	15	3	2
Apr 2010	17	7	4
May 2010	13	10	7
Jun 2010	9	3	4
Jul 2010	14	1	5
Aug 2010	11	3	2
Sep 2010	13	1	2
Oct 2010	18	4	1
Nov 2010	18	4	1
Dec 2010	6	1	3
Jan 2011	8	2	1
Feb 2011	13	1	3
Mar 2011	14	2	3
Apr 2011	12	2	6
May 2011	13	2	4
Jun 2011	11	0	1
Jul 2011	10	9	3
Aug 2011	15	2	0
Sep 2011	6	1	3
Oct 2011	18	2	4
Nov 2011	20	11	9
Dec 2011	11	8	4
Jan 2012	11	9	8
Feb 2012	16	9	4
Mar 2012	10	10	4
Apr 2012	11	5	10
May 2012	14	9	6
Jun 2012	11	9	6
Jul 2012	22	6	5
Aug 2012	16	5	5
Sep 2012	11	16	15
Oct 2012	18	14	12
Nov 2012	19	17	6
Dec 2012	19	15	10
Jan 2013	16	13	6
Feb 2013	20	18	6
Mar 2013	20	19	4
Apr 2013	12	26	6
May 2013	8	21	13
Jun 2013	5	12	3
Jul 2013	10	12	5
Aug 2013	11	6	3
Sep 2013	8	2	5
Oct 2013	8	10	5
Nov 2013	6	7	1
Dec 2013	15	9	8
Jan 2014	16	18	9
Feb 2014	5	15	3
Mar 2014	13	26	5
Apr 2014	12	25	6
May 2014	33	26	8
Jun 2014	6	21	4
Jul 2014	15	20	3
Aug 2014	10	15	3
Sep 2014	8	10	2
Oct 2014	5	5	6
Nov 2014	25	8	5
Dec 2014	12	6	2
Jan 2015	4	7	2
Feb 2015	3	6	5
Mar 2015	24	29	6
Apr 2015	3	15	2
May 2015	19	14	3
Jun 2015	5	16	1
Jul 2015	7	10	4
Aug 2015	4	13	1
Sep 2015	10	3	2
Oct 2015	5	3	0
Nov 2015	9	5	1
Dec 2015	10	9	3
Jan 2016	21	8	5
Feb 2016	10	16	4
Mar 2016	9	14	13
Apr 2016	6	10	4
May 2016	12	14	2
Jun 2016	12	8	3
Jul 2016	8	7	3
Aug 2016	9	11	0
Sep 2016	5	7	3
Oct 2016	17	22	9
Nov 2016	18	21	6
Dec 2016	21	10	1
Jan 2017	17	19	4
Feb 2017	6	20	2
Mar 2017	8	16	3
Apr 2017	4	20	0
May 2017	7	41	3
Jun 2017	20	36	3
Jul 2017	22	20	2
Aug 2017	25	22	9
Sep 2017	78	60	13
Oct 2017	91	79	11
Nov 2017	67	59	8
Dec 2017	80	70	2
Jan 2018	66	58	2
Feb 2018	81	77	9
Mar 2018	98	90	5
Apr 2018	117	95	6
May 2018	88	82	5
Jun 2018	110	106	5
Jul 2018	137	123	9
Aug 2018	142	140	5
Sep 2018	144	136	5
Oct 2018	199	189	7
Nov 2018	177	175	5
Dec 2018	128	126	4
Jan 2019	152	148	4
Feb 2019	122	121	7
Mar 2019	146	144	7
Apr 2019	146	144	8
May 2019	168	168	9
Jun 2019	156	152	9
Jul 2019	155	153	11
Aug 2019	140	138	5
Sep 2019	105	101	6
Oct 2019	97	97	11
Nov 2019	93	89	6
Dec 2019	86	86	5
Jan 2020	104	100	3
Feb 2020	82	80	3
Mar 2020	83	81	7
Apr 2020	52	52	9
May 2020	42	38	6
Jun 2020	36	34	1
Jul 2020	42	42	5
Aug 2020	23	23	2
Sep 2020	45	41	4
Oct 2020	67	63	11
Nov 2020	57	49	8
Dec 2020	53	51	7
Jan 2021	57	55	4
Feb 2021	36	32	7
Mar 2021	33	29	0
Apr 2021	37	35	5
May 2021	46	46	4
Jun 2021	55	55	3
Jul 2021	39	39	5
Aug 2021	50	50	9
Sep 2021	47	47	12
Oct 2021	42	40	17
Nov 2021	13	13	14
Dec 2021	18	18	1
Jan 2022	16	13	2
Feb 2022	19	19	1
Mar 2022	39	40	7
Apr 2022	80	76	4
May 2022	84	82	14
Jun 2022	56	57	4
Jul 2022	50	41	5
Aug 2022	41	40	3
Sep 2022	54	50	7
Oct 2022	106	100	9
Nov 2022	83	74	12
Dec 2022	65	64	13
Jan 2023	76	68	7
Feb 2023	67	67	4
Mar 2023	95	98	14
Apr 2023	66	62	9
May 2023	55	50	21
Jun 2023	47	49	24
Jul 2023	62	61	12
Aug 2023	75	72	6
Sep 2023	46	47	8
Oct 2023	64	64	4
Nov 2023	83	86	8
Dec 2023	92	92	0
Jan 2024	36	36	2
Feb 2024	49	49	7
Mar 2024	57	58	31
Total	8334	8561	1860

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