Article Text

PDF

Amoxycillin levels in sputum, serum, and saliva
  1. Sheila M. Stewart,
  2. Isobel M. E. Anderson,
  3. G. R. Jones,
  4. Margaret A. Calder,
  5. C. Pratt,
  6. Margaret G. G. Malcolm
  1. Departments of Bacteriology and Respiratory Diseases, University of Edinburgh and the City Hospital, Edinburgh

    Abstract

    Stewart, Sheila M., Anderson, Isobel M. E., Jones, G. R., and Calder, Margaret A. (1974).Thorax, 29, 110-114. Amoxycillin levels in sputum, serum, and saliva. The levels of amoxycillin in sputum, saliva, and serum from 22 patients were estimated. Fifteen patients had pneumonia and seven had acute exacerbations of chronic bronchitis. The drug was given orally in a dose of 500 mg four times daily.

    There was considerable variation in the levels in specimens from different patients. The mean sputum levels two to three hours and six hours after the dose were 0·52 and 0·53 μg/ml respectively. The mean two-hour saliva level was 0·32 μg/ml. The mean serum levels two and six hours after the test dose were 11·0 and 3·5 μg/ml respectively. The higher levels of amoxycillin were usually associated with the presence of more pus in the sputum. The mean levels of amoxycillin at comparable times were significantly greater than those found in a previous study after the same dose of ampicillin.

    Clinical response to treatment occurred more rapidly in those patients with sputum levels of 0·25 μg amoxycillin per ml or above than in those with lower levels. The time taken to clear potential pathogens from the sputum was related to the pathogen rather than to the amoxycillin level, Haemophilus influenzae persisting for longer than Streptococcus pneumoniae.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.