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Haemodynamic effects of oral aminorex and amphetamine in unanaesthetized beagle dogs
  1. James A. Will1,
  2. Gerald E. Bisgard
  1. Cardiovascular Research Laboratory, Department of Medicine, University of Wisconsin Medical School, Madison, Wisconsin 53706
  2. Department of Veterinary Science, College of Agriculture and Life Sciences, University of Wisconsin, Madison, Wisconsin 53706

    Abstract

    The haemodynamic effects of four daily oral doses of 1·5 mg/kg of aminorex (as fumarate) were measured in unanaesthetized beagle dogs. A similar study was performed in another group of related animals using d-amphetamine sulphate (1 mg/kg). Both agents produced similar sympathomimetic effects consisting of transient rises in systemic and pulmonary arterial blood pressures over an eight-hour period after administration of either drug. Heart rate remained unchanged in the dogs receiving aminorex whereas it decreased in those receiving amphetamine.

    There was no cumulative or residual haemodynamic effect of either drug. We therefore conclude that neither aminorex nor amphetamine readily produces sustained pulmonary hypertension in beagle dogs.

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    Footnotes

    • 1 Requests for reprints to: Dr. James A. Will, Cardiovascular Research Laboratory, 420 North Charter, Room 523, Madison, Wisconsin 53706

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