Article Text

PDF

An evaluation of azathioprine in severe chronic asthma
  1. N. G. Hodges1,
  2. R. A. L. Brewis,
  3. J. B. L. Howell
  1. Manchester Royal Infirmary, Manchester

    Abstract

    Previous studies of immunosuppressive therapy in asthma have been uncontrolled and conflicting in their results. Two double-blind controlled cross-over trials using two dosage levels of azathioprine (2 mg/kg and 5 mg/kg for three and four weeks respectively) in a total of 20 patients with chronic severe asthma are described. Both objective and subjective assessments by independent observers indicated no significant change in the groups as a whole. However, in four patients, an improvement was attributed to azathioprine therapy. Two patients in whom sputum production was copious showed marked clinical improvement and reduced sputum volume. In four patients, exacerbations of asthma occurred within two weeks of starting azathioprine and a causal relationship was suspected. No serious depression of circulating white blood cells occurred in any patient.

    Statistics from Altmetric.com

    Footnotes

    • 1 Correspondence to N.G.H., Southampton General Hospital, Southampton

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.