Article Text

PDF

`Metered' aerosols of bronchodilator drugs in clinical trials
  1. Burton M. Cohen
  1. The New Jersey College of Medicine and Dentistry, Elizabeth, N.J.2

    Influence of the method of administration 1

    Abstract

    Airway resistance, the volume of thoracic gas, and specific airway resistance were determined before and after administration of an isoproterenol-phenylephrine mist in random fashion to 20 patients with obstructive ventilatory disorders from a hand-triggered apparatus either used by the patient or given by the physician, and from a nebulizer automatically activated by patient inspiration. Specific airway resistance changes were the most sensitive guide to broncholytic effects. Maximal change followed exposure to the breath-activated unit, suggesting that its use in similar drug trials may reduce an important source of error in estimates of the efficacy of bronchopulmonary aerosols.

    Statistics from Altmetric.com

    Footnotes

    • 1 Read at the VII International Congress of Allergology, Florence, Italy, October 12-17, 1970

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.