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Haemodynamic effects of dextro-propranolol in acute myocardial infarction
  1. David Bennet,
  2. Raphael Balcon,
  3. Judith Hoy,
  4. Edgar Sowton1
  1. Institute of Cardiology, 35 Wimpole Street, London, W.1

    Abstract

    Intravenous injections of 20-25 mg. d-propranolol did not change the heart rate or systemic pressure in 13 patients with cardiac infarction. Cardiac output was depressed in 10, but there was no clinical deterioration. d-Propranolol was better tolerated than dl-propranolol under these conditions and justifies further investigation as an anti-dysrhythmic agent. The major depressant effects of dl-propranolol following cardiac infarction appear to be due to beta-adrenergic blockade and not to a direct depressant action on cardiac muscle.

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    Footnotes

    • 1 Correspondence to Dr. E. Sowton

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