Two patients with aspergillus mycetoma presenting with fever as a major sign are described. The clinical presentation is correlated with the results of experimental inhalation of Aspergillus fumigatus extract in patients with aspergillus mycetoma. A theory is put forward which tries to explain fever and haemoptysis as belonging to a type III (Gell and Coombs, 1963) antigen-antibody reaction. Therapeutic implications are discussed.
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