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Intrinsic mechanisms controlling the mammalian gastro-oesophageal sphincter deprived of extrinsic nerve supply
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  1. Charles V. Mann,
  2. Charles F. Code,
  3. Jerry F. Schlegel,
  4. F. Henry Ellis, Jr.
  1. Section of Physiology, University of Minnesota, Rochester, Minn., U.S.A.
  2. Section of Surgery, Mayo Clinic and Mayo Foundation, University of Minnesota, Rochester, Minn., U.S.A.
  3. Mayo Graduate School of Medicine, University of Minnesota, Rochester, Minn., U.S.A.

    Abstract

    The oesophagus and gastro-oesophageal junction of 13 guinea-pigs and 14 3-week-old kittens were removed and placed in oxygenated Tyrode's solution at 36 to 37° C. Sphincteric pressures were recorded before and after oesophageal distension. In these preparations changes in the tone of the gastro-oesophageal sphincter were observed in response to lower oesophageal distension. The sphincter of the guinea-pig responded by relaxation, whereas the sphincter of the kitten responded more often by contraction. The relaxation/contraction responses of the sphincter to oesophageal distension were independent of any extrinsic nerve supply and could be abolished by removal of a circular cuff of oesophageal muscle between the source of the stimulus and the gastro-oesophageal sphincter. The intramural mechanisms affecting gastro-oesophageal sphincteric tone probably are present in all mammals, including man.

    https://doi.org/10.1136/thx.23.6.634

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