Article Text

PDF

Pulmonary changes and cor pulmonale in mucoviscidosis
  1. Paul Wentworth,
  2. Jethro Gough,
  3. James E. Wentworth
  1. Departments of Pathology, the Hospital for Sick Children, Toronto, Canada
  2. Welsh National School of Medicine, the Royal Infirmary, Cardiff, Wales

    Abstract

    The lungs of eight cases of cystic fibrosis in patients ranging from age 19 days to 23 years were examined by the large-section technique of Gough and Wentworth (Gough, 1960). All cases showed in life a susceptibility to staphylococcal and pseudomonal bronchopneumonia. In all cases the bronchial tree was plugged with mucus. The lungs from the older patients showed diffuse and pronounced bronchiectasis with luxuriant peribronchial granulation tissue and dilatation of the pulmonary arterial system. The distal air spaces in all cases showed only minimal distension and only in the eldest was there any evidence of destructive emphysema. Three cases developed cor pulmonale which we thought was the result of hypoxaemia due to a ventilation-perfusion imbalance.

    Statistics from Altmetric.com

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.