Article Text

PDF

Cell kinetics and tumour formation
  1. Matthew B. Divertie,
  2. Roy G. Shorter,
  3. Jack L. Titus
  1. Section of Medicine, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, U.S.A.
  2. Section of Surgical Research, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, U.S.A.
  3. Section of Experimental and Anatomic Pathology, Mayo Clinic and Mayo Foundation, Rochester, Minnesota, U.S.A.

    Abstract

    Cell turnover time varies from one tissue to another but is reproducible as a hereditary characteristic for a given cell line. The present study indicates that it is prolonged in the lungs of mice congenitally predisposed to developing primary lung tumours. Primary malignant tumours occur more frequently in areas of relatively slow cell replacement in the human gastrointestinal tract than in those where cell turnover is rapid. On the basis of these observations it is suggested that postmaturity of a cell may be a significant factor in the development of neoplastic change.

    Statistics from Altmetric.com

    Footnotes

    • 1 This work was supported in part by grants CA06782 and CA08632 from the National Institutes of Health, U.S.P.H.S.

    Request permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.