Thorax 22:176-179 doi:10.1136/thx.22.2.176
  • Articles

Pulmonary hypertension produced in rats by ingestion of Crotalaria spectabilis seeds

  1. J. Michael Kay,
  2. Peter Harris,
  3. Donald Heath
  1. Department of Pathology, University of Birmingham
  2. Department of Medicine, University of Birmingham


      The oral administration of Crotalaria spectabilis seeds to young rats induces pulmonary hypertension in them associated with right ventricular hypertrophy and an increase in the medial thickness of the pulmonary trunk and muscular pulmonary arteries. This appears to be the first direct demonstration that the oral administration of an agent may bring about pulmonary hypertension.