Is childhood immunisation associated with atopic disease from age 7 to 32 years?

Kazunori Nakajima ¹, Shyamali C Dharmage ^1*, John B Carlin ¹, Cathryn L Wharton ¹, Mark A Jenkins ¹, Graham G Giles ², Michael J Abramson ³, E Haydn Walters ⁴ and John L Hopper ¹

¹ The University of Melbourne, Australia
² The University of Melbourne, Cancer Council Victoria, Australia
³ Monash University, Australia
⁴ University of Tasmania, Australia

^* To whom correspondence should be addressed. E-mail: s.dharmage{at}unimelb.edu.au.

Accepted 15 September 2006

Abstract

Background: There is ongoing conjecture over whether childhood immunisation leads to an increased risk of developing atopic diseases.

Objective: To examine associations between childhood immunisation and the risk of atopic disease.

Methodology: Immunisation histories of 8,443 Tasmanian children born in 1961 obtained from School Medical Records were linked to the Tasmanian Asthma Study. Associations between immunisation status and atopic diseases were examined while adjusting for possible confounders using multiple logistic regression.

Results: Diphtheria immunisation was weakly associated with an increased risk of asthma by age 7 years (OR 1.3, 95% CI 1.1-1.7), but there was no evidence of any association for four other vaccinations studied. An increased risk of eczema by age 7 years was associated with immunisation against diphtheria (OR 1.5, 95% CI 1.1-2.1), tetanus (OR 1.5, 95% CI 1.1-2.0), pertussis (OR 1.5, 95% CI 1.1-1.9) and polio (OR 1.4, 95% CI 1.0-1.9) but not small pox. Similar but slightly weaker patterns of association were observed between the risk of food allergies and immunisation against diphtheria (OR 1.5, 95% CI 1.0-2.1), pertussis (OR 1.4, 95% CI 1.1-1.9), polio (OR 1.4, 95% CI 1.00-2.1) and tetanus (OR 1.30 95% CI 0.99-1.70), but not with small pox. There was no evidence of associations between immunisation history and hay fever, or incidence of later-onset atopic outcomes.

Conclusions: The few effects seen in this study are small and age-dependent, and nearly all our findings support numerous previous studies reporting no effect of vaccines on asthma. Based on these findings the fear of their child developing atopic disease should not deter parents from immunizing their children, especially when weighed against the benefits.

Keywords: Asthma, Atopic disease, Immunisation, Tasmanian Asthma Study

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

Relevant Article

Airwaves

Wisia Wedzicha
Thorax 2007 62: 193. [Extract] [Full Text] [PDF]

This article has been cited by other articles:

• Spycher, B. D., Silverman, M., Egger, M., Zwahlen, M., Kuehni, C. E. (2009). Routine Vaccination Against Pertussis and the Risk of Childhood Asthma: A Population-Based Cohort Study. Pediatrics 123: 944-950 [Abstract] [Full Text]  
• Bernsen, R M, van der Wouden, J C, Dharmage, S C, Matheson, M, Nakajima, K, Carlin, J B, Wharton, C, Jenkins, M A, Giles, G, Hopper, J, Walters, E H, Abramson, M (2007). Is childhood immunisation associated with atopic disease from age 7 to 32 years?. Thorax 62: 925-926 [Full Text]