IMAGES IN THORAX

Delayed-onset bronchiolitis obliterans with organising pneumonia associated with massive acetic acid steam inhalation

B-F Sheu¹, C-C Lee², Y-R Young¹, L-F Li³ and S-S Chang^1,4

¹ Department of Emergency Medicine, Chang Gung Memorial Hospital and Chang Gung College of Medicine, Taoyuan, Taiwan
² Department of Emergency Medicine, National Taiwan University Hospital Yun-Lin Branch, Douliou, Taiwan
³ Department of Chest Medicine, Chang Gung Memorial Hospital, Taoyuan, Taiwan
⁴ Department of Nursing, Chang Gung Institute of Technology, Taoyuan, Taiwan

Correspondence to:
Dr C-C Lee, Department of Emergency Medicine, National Taiwan University Hospital, No. 7 Chung-Shan South Road, Taipei 100, Taiwan; chnchnglee{at}yahoo.com

A 34-year-old worker had massive exposure to acetic acid steam from an explosion in a chemical factory. At the emergency department respiratory distress, hoarseness and swelling of the oropharyngeal mucosa were noted. The chest radiograph showed bilateral infiltration (fig 1). After being diagnosed with inhalation injury and chemical pneumonitis, he was prophylactically intubated and given parenteral steroid with prophylactic antibiotics. Diagnostic fibreoptic bronchoscopy revealed diffuse trachobronchial mucosal redness and friability (fig S1A,B available online only). Scattered throughout the airway were multiple corrosive ulcerations. A follow-up thin-section CT scan at day 15 showed ground-glass attenuation in the bilateral upper lung (fig 2). Lower sections of the chest CT scan did not show signs of severe airway obstruction. At day 21 he began to feel chest tightness and dyspnoea and had massive repeated haemo-ptysis. Repeated bronchoscopy showed diffuse mucosal pallor, scattered ulcerations, fibrous exudates and granulation tissue in the lower trachea, right upper bronchi and more distal bronchioles (fig S1C, D available online only).

View larger version (107K): in this window | in a new window | PowerPoint for Teaching   Figure 1 Initial chest radiograph showing bilateral perihilar infiltrates.

 

View larger version (159K): in this window | in a new window | PowerPoint for Teaching   Figure 2 (A) High-resolution CT scan showing diffuse ground-glass attenuation in the bilateral upper lungs. Scattered areas of air trapping are visible (arrows). (B) Lower section showing only scattered peribronchovascular ground-glass attenuation (arrow). Patchy consolidation is evident (arrowhead).

 

Delayed-onset bronchiolitis obliterans organising pneumonia (BOOP) due to acetic acid steam inhalation was diagnosed. He died of an episode of methicillin-resistant Staphylococcus aureus infection of the bloodstream with multiple organ failure 1 month later.

The natural course of pulmonary injury associated with acetic acid steam exposure has not been documented. Our patient experienced a biphasic clinical response characterised by acute pulmonary oedema followed by delayed-onset BOOP, similar to that observed in other cases of irritant gas exposure.¹ The most common symptoms of BOOP are a progressive dry cough, effort dyspnoea, low-grade pyrexia and malaise. Patients with BOOP rarely present with a large amount of haemoptysis and this posed a great diagnostic challenge initially.²

FOOTNOTES

Figure S1 is published online only at http://thorax.bmj.com/content/vol63/issue6

Competing interests: None.

REFERENCES

TOP REFERENCES

1. Do Pico GA. Toxic gas inhalation. Curr Opin Pulm Med 1995; 1: 102–8.[Medline]
2. Epler GR. Bronchiolitis obliterans organizing pneumonia. Arch Intern Med 2001; 161: 158–64.[Abstract/Free Full Text]

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