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A mixed methods study to compare models of spirometry delivery in primary care for patients at risk of COPD

¹ Menzies Research Institute, University of Tasmania, Australia

Correspondence to:
Dr J A Walters, Menzies Research Institute, PB 34, Clinical School, University of Tasmania, Hobart 7001, Australia; Julia.Walters{at}utas.edu.au

Received 17 April 2007
Accepted for publication 1 November 2007

	ABSTRACT

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
Background: To increase recognition of airflow obstruction in primary care, we compared two models of spirometry delivery in a target group at risk of chronic obstructive pulmonary disease (COPD).

Methods: A 6 month qualitative/quantitative cluster randomised study in eight practices compared opportunistic spirometry by "visiting trained nurses" (TN) with optimised "usual care" (UC) from general practitioners (GPs) for smokers and ex-smokers, aged over 35 years. Outcomes were: spirometry uptake and quality, new diagnoses of COPD and GPs’ experiences of spirometry.

Results: In the eligible target population, 531/904 (59%) patients underwent spirometry in the TN model and 87/1130 (8%) patients in the UC model (p<0.0001). ATS spirometry standards for acceptability and reproducibility were met by 76% and 44% of tests in the TN and UC models, respectively (p<0.0001). 125 (24%) patients tested with the TN model and 38 (44%) with the UC model reported a pre-existing respiratory diagnosis (p<0.0001). Three months after spirometry, when the ratio of forced expiratory volume in 1 s/forced vital capacity (FEV₁/FVC) was <0.7 and no prior COPD diagnosis was reported, nine (8%) participants had a new doctor recorded COPD diagnosis in practices with the TN model and two (8%) participants in practices with the UC model. Mislabelling of participants with a diagnosis of COPD when FEV₁/FVC was 0.7 was present in both models prior to and after spirometry. GPs valued high quality spirometry and increased testing of patients at risk of COPD in the TN model. They identified limitations, including the need for better systematic follow-up of abnormal spirometry and support with interpretation, which may explain persisting underdiagnosis of COPD in practice records.

Conclusions: Although opportunistic testing by visiting trained nurses substantially increased and improved spirometry performance compared with usual care, translating increased detection of airflow obstruction into diagnosis of COPD requires further development of the model.

Trial registration number: Australian Clinical Trials Registry: registration No 12605000019606.

	METHODS

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
Participants and study design
Practices were recruited through a newsletter distributed to all practices in Southern Tasmania (74 urban/suburban and 20 rural). Six urban and two rural general practices responded and were included and randomised. The study protocol was approved by the Southern Health and Medical Human Research Ethics Committee. Signed informed consent was obtained from GPs in participating practices and from patients at recruitment, which occurred between November 2004 and June 2005.

Spirometry delivery models
Using a random numbers table, practices were randomised to models for delivery of spirometry to patients in the target group at risk of COPD defined by: age over 35 years and ever smoked regularly. In the trained nurse model (TN), nurses trained in spirometry testing visited each practice for two 3 h sessions per week to perform opportunistic testing. Practice staff invited any patient in the target group who attended during a spirometry session to undergo lung function testing. Spirometry was also advertised by posters or performed at the request of GPs. Printed spirometer output (without classification or interpretation) was faxed to GPs within 48 h.

In the usual care model (UC) model, a spirometer was provided to the practice and education and spirometry training given. After training, spirometry was performed by a GP or practice nurse/assistant according to the usual practice protocol. Practice publicity was discretionary (eg, computer generated reminders or posters). Practices retained spirometry traces for GP interpretation and received reimbursement for patients tested in the target group (AUS$10, proportionate to an existing Australian Medicare schedule fee for spirometry with reversibility testing).

Spirometry training
In practices receiving either intervention, GPs and other nominated staff were trained during a 2 h workshop (see appendix 1) by a physiologist and respiratory specialist physician in performance of spirometry (theory and practice), interpretation and criteria for diagnosing COPD according to Global Initiative for Chronic Obstructive Lung Disease (GOLD)⁴ and Australian⁵ guidelines (forced expiratory volume in 1 s/forced vital capacity (FEV₁/FVC) <0.7).

Outcome data collection
Spirometry uptake and acceptability
Demographic data were collected for all patients offered spirometry. Additionally, reasons for accepting or refusing spirometry were recorded for patients offered an opportunistic test. Participants undergoing spirometry completed questionnaires recording smoking history, assessment of functional breathlessness using the Medical Research Council (MRC) dyspnoea scale⁹ and self-reported use of respiratory medications and diagnoses.

Spirometry
Spirometry was performed in all practices using an ultrasonic electronic spirometer (EasyOne, NDD Medizintechnik AG, Technoparkstrasse, Switzerland). This spirometer has the advantage of stability,¹⁰ inbuilt quality assurance features,¹¹ classifies tests using grades (A–D, F) for reliability (see appendix 2) and provides prompts to optimise performance. Investigators performed regular calibration checks. A spirometry test consisted of three expiratory manoeuvres (emphasising full inspiration and complete exhalation) meeting American Thoracic Society (ATS) acceptability and repeatability criteria, performed without bronchodilator reversibility testing.¹¹ The time to complete testing was recorded in the TN model. Predicted values were calculated from Knudson and colleagues.¹² Reports provided to GPs included the parameters FEV₁, FVC, FEV₁/FVC ratio, forced expiratory flow (FEF)_25–75%,, peak expiratory flow and forced expiratory time for three acceptable manoeuvres with corresponding flow–volume and volume–time curves.

Quality assurance
Spirometry was assessed by investigators against contemporary ATS criteria¹¹ for acceptability and repeatability (see appendix 2). The proportions of acceptable spirometry that showed a difference between the best two FEV₁ and best two FVC 200 ml (grade A or B) were compared between models. The utility of spirometry for interpretation by GPs was evaluated by assessing the proportion of spirometry of poor quality grades (D, two acceptable but not repeatable tests; F, only one acceptable test or no acceptable test achieved).

Impact of spirometry on diagnosis of COPD
A definition of the presence of airflow obstruction (AO) based on the principal criterion (FEV₁/FVC <0.7) specified in (GOLD) guidelines⁴ was used for investigator assessment of a doctor diagnosis of COPD following spirometry.¹³ When spirometry met any of the following criteria, practice records of patients belonging to the target group were examined by investigators 3 months later: FEV₁/FVC <85% predicted, FEV₁ <80% predicted, FVC <80% predicted or FEF_25–75% <55% predicted. Data were extracted on further investigations by GPs, including post-bronchodilator spirometry, and doctor recorded diagnoses of respiratory disease before and after spirometry.

Qualitative assessment of spirometry delivery models
At the conclusion of the study, focus group discussions were conducted with GPs in each practice. A trained facilitator used both general and specific questions relevant to each spirometry model with case scenarios to generate discussion.¹⁴

Statistical analysis
Two trained nurses were expected to recruit a maximum of 30 patients per week for opportunistic spirometry. No data on the rate of spirometry refusal in the target group were available. Assuming a 25% refusal rate, we anticipated testing a maximum of 1170 participants in four TN practices. Based on a previous study,⁷ the expected rate of spirometry was 2.3 tests per week, 240 tests in UC practices. Planned comparisons were the number of tests performed in 6 months and proportions of the eligible target group tested in practices. The eligible population in the TN model consisted of patients in the target group who attended for any reason during spirometry sessions over 6 months, calculated as the number invited plus those who missed an invitation to participate. The eligible population in the UC model consisted of all patients in the target group who consulted a GP at least once during the study. This was calculated from consultation numbers during 6 months minus: numbers of lifelong non-smokers and under 35 year of age, allowing for the proportion of patients making repeat attendances estimated from attendance data extracted from practice records. Quantitative data analyses were performed using SPSS V.14.0 and STATA V.10. Variables are presented as means (SD) or median (interquartile range (IQR)) if non-normally distributed. Clustering was taken into account in regression analyses with random intercepts using multi-level mixed effects linear models or generalised linear latent and mixed models. Comparison of proportions tested in practices was performed using a t test weighted by the number of eligible patients.¹⁵ Statistical significance was set at the 5% level.

Qualitative data were analysed using NVivo (V.2, Qualitative Solutions and Research International, Melbourne, Victoria, Australia). Focus group discussions were audiotaped and transcribed verbatim. An iterative process of inductive category development was used for content analysis.¹⁴ Two researchers (JW, JG or EH) listened to all tapes to identify the initial themes. JW analysed transcripts line-by-line, coded relevant themes and categories, and recorded thematic development using memos. Emergent themes were verified by EH and discussed among all authors. Themes and sub-themes were compared by spirometry delivery models. Examples of quotes were used to illustrate themes.

	RESULTS

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
Spirometry uptake, application and feasibility
Opportunistic spirometry was performed on 531 participants in the target group of patients in the TN model while 87 participants in the target group were tested by GPs or practice nurses in the UC model over a period of 6 months. There was a significant difference between proportions of the estimated eligible target group population that underwent spirometry in practices in the TN model and in practices with the UC model (p<0.0001), overall 58.7 versus 7.7% (fig 1).

View larger version (24K): [in this window] [in a new window] [PowerPoint for Teaching]   Figure 1 Study flow chart. FTE, full time equivalent; GP, general practitioner; PN, practice nurse. Target group: age 35 years, smoker or ex-smoker.

View this table: [in this window] [in a new window]   Table 1 Characteristics of patients belonging to the target group (age 35 years, ever smoker) undergoing spirometry in practices by spirometry delivery model

Impact of spirometry on diagnosis of COPD
Examination of practice records
A total of 277 (52%) tests conducted in the TN model and 39 (45%) tests conducted in the UC model did not meet the pre-specified spirometric criteria for proceeding to practice record data extraction. In patients whose spirometry met the criteria, data extraction was successfully completed for 266 (89%) patients in practices with the TN model and in 40 (83%) patients in practices with the UC model. Records for 37 patients were unavailable to investigators.

In practices with the TN spirometry model, 190 (84%) patients had consulted a GP by 3 months after spirometry and in these patients there were 11 new doctor recorded diagnoses of COPD, 2.2% of participants without prior self-reported COPD (fig 2). When spirometry demonstrated airflow obstruction (FEV₁/FVC <0.7), there were nine new doctor recorded diagnoses of COPD, an 8.3% increase by 3 months following spirometry. Two patients with an FEV₁/FVC ratio 0.7 had a new doctor recorded COPD diagnosis. Among participants with a prior self-reported diagnosis of COPD, 19 (60%) demonstrated airflow obstruction. In practices with the UC spirometry model, two (8%) participants with airflow obstruction received a new doctor recorded diagnosis of COPD (fig 2). Among those with a prior self-reported COPD diagnosis, four (36%) demonstrated airflow obstruction.

View larger version (26K): [in this window] [in a new window] [PowerPoint for Teaching]   Figure 2 Impact of spirometry on the diagnosis of chronic obstructive pulmonary disease (COPD) in practices receiving the visiting trained nurse (TN) or usual care (UC) model of spirometry delivery. AO, spirometry demonstrated airflow obstruction forced expiratory volume in 1 s/forced vital capacity (FEV1/FVC) <0.7. Target group: age 35 years, smoker or ex-smoker.

GP experience
Fifteen GPs (52%) from practices with the TN model and 13 GPs (68%) from practices with the UC spirometry model participated in six in-depth focus groups. Of the major themes that emerged (table 3), some were important for GPs from practices with either spirometry model, such as the need for appropriate spirometry reimbursement and the necessity of achieving high quality results. Only in practices with the UC model did GPs emphasise their own difficulties in performing spirometry and the paramount importance of having a practice nurse to perform spirometry testing. GPs in practices with the TN model thought GP initiated spirometry would be unlikely in the absence of a prior diagnosis and felt that opportunistic spirometry had major advantages for convenience and acceptability to patients. This was particularly relevant for smokers who might be reluctant to raise concerns about respiratory symptoms with GPs, because they felt guilty about self-induced lung damage. Organised follow-up, specifically focussed on spirometry, was thought essential in both models of spirometry, but a recall system after opportunistic testing would increase an already heavy GP workload and increase costs for patients in Australian primary care.

The most likely consequences of spirometry elicited from GPs in both spirometry models were being prompted to identify and record patients’ smoking status and initiate discussion on cessation. Spirometry, even when normal, was used to personalise and reinforce advice on quitting.

	DISCUSSION

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
This study was unique in using qualitative assessment to explore and validate quantitative findings^{16 17} of the impact of two models of delivery of spirometry in general practice.¹⁸ We found that opportunistic trained nurse performed spirometry led to a substantially higher proportion of the population at risk of developing COPD having spirometry performed compared with usual care by GPs equipped and trained in spirometry. Spirometry performed in both models resulted in an increase in GP diagnosis of COPD. However, in practices with the visiting TN model, substantial underdiagnosis remained after a period that allowed for follow-up and further investigations in patients with spirometric evidence of airflow obstruction.

Direct invitations for spirometry by a nurse were highly acceptable to patients and GPs, although we had a higher non-participation rate compared with other similar studies,^{3 19} mainly caused by time constraints and illness in this opportunistic testing model within the GP clinic. However, the study design aimed to reflect busy "real world" general practice, both without pre-selection or exclusions in the target group and in utilisation and interpretation of spirometry by GPs.

The high proportion of visiting nurse performed spirometry satisfying ATS standards for acceptability and repeatability¹¹ was similar to that reported in studies using trained staff in general practice^{3 20} or in the community²¹ and greater than achieved in practices with the UC model where the quality was variable and reflected the lack of GP expertise self-identified in our qualitative data. There was a consensus that the nature of GPs’ work was not compatible with performing spirometry to consistently high standards, but this could be achieved with adequate training and experience by practice nurses. A low rate of good quality testing in practice was found previously⁷ although a recent study found higher rates achieved in some practices with intensive 2 day spirometry training.²²

Use of spirometry without post-bronchodilator measurement in order to limit refusals²³ may overestimate the prevalence of airflow obstruction in each model. However, more mild obstruction was identified by opportunistic testing compared with testing in the UC model or as reported in an open access spirometry service for GPs in the UK.²¹ Spirometry use for a diagnosis of COPD is low with models that rely on GP initiation or referral.^{24 25} Our qualitative data indicated that initiation of testing may not occur in the absence of previously identified disease with known underreporting by patients of symptoms.²⁶

This study investigated the utility of different spirometry models to increase the diagnosis of COPD in actual primary care practice. The high level of missed opportunities for new diagnosis in patients with airflow obstruction and mislabelling of COPD found in practice record review are consistent with findings in other studies in primary care.^{7 13 27} Methods suggested by GPs to improve interpretation seem feasible and deserve further investigation.²⁸ In addition to failure to interpret spirometry correctly, qualitative data analysis identified other factors contributing to non-diagnosis, including non-consultation by patients, time limitations and GPs’ preference for reactively addressing the patient’s own agenda during a consultation rather than being proactive. These factors have also been found to be deterrents to GPs initiating discussions with smokers.²⁹

Cost effectiveness of spirometry for case finding in COPD will vary if a symptom screening tool is used³⁰ but depends on subsequent reduced costs through better management and reduced progression of the disease resulting from successful smoking cessation.³¹ While we found GPs valued opportunistic testing primarily to improve identification of smoking status and initiate discussion on cessation, there is still no definitive conclusion on a positive impact of spirometry on smoking cessation.³²

Consideration of the value of spirometry in primary care and choice of the most effective model for delivery requires a full cost–benefit analysis. Although data on costs have been generally lacking for other models they are included here to facilitate comparison.^{13 21} A cost–benefit analysis using data on opportunistic testing in patients at risk of COPD³ carried out for the National Institute of Clinical Excellence³³ found spirometry was relatively cost effective in case finding (assuming optimum interpretation) compared with current practice in primary care. Incomplete follow-up of airflow obstruction detected on spirometry caused a large increase in cost per case in our study.

Our analysis assumes participating practices were a random sample of those in Southern Tasmania but although they contained a representative range, we cannot discount selection bias and the findings may not be generalisable to all primary care practice. UC model practices had involvement in medical training and willingness to participate in research. They may be more knowledgeable about guidelines and perform more spirometry than others.³⁴

We conclude that it is possible to increase spirometry for case finding in primary care using a model of testing by visiting trained nurses. However, to translate increased detection of airflow obstruction into increased COPD diagnosis requires measures to overcome issues identified by qualitative analysis and, at the very least, provide GPs with assistance in interpretation of spirometry.¹⁸

	Appendix 1

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
Spirometry Training Course: for general practitioners and practice nurses
Instructors: respiratory specialist physician, pulmonary physiologist, GP.

Course content

• Spirometry performance (40 min)
  
• • Demonstration of simple spirometry spirogram and complex spirometry flow volume loop
    
  • Potential complications of spirometry
    
  • Contraindications to spirometry:
    
  • Requirements for achieving consistently high quality spirometry
    
  • Test performance instructions
    
  • Acceptance criteria (need to obtain at least 3 technically acceptable blows)
    
  • Reproducibility criteria
    
  • Common causes of poor quality spirometry
    
  • How to get quality spirometry
    
  • Trouble shooting: patient related (with examples of curves)
    
  • Interpretation: types of ventilatory defects
    
  • Use of predicted values
    
  
  
• Demonstration using EasyOne spirometer and software (20 min)
  
• Practice spirometry with EasyOne (30 min)
  
• Spirometry: application in COPD (30 min)
  
• • Diagnosis of COPD, differentiation from asthma
    
  • Interpretation of airflow obstruction and classification of severity
    
  • COPDX guidelines—indications for spirometry
    
  • Review of clinical case examples.
    
  
  

	Appendix 2

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
Acceptability assessment

1. Spirometry test did not meet EasyOne spirometer criteria for an unacceptable test:
   
2. 1. back extrapolated volume greater than 150 ml or 5% whichever is greater;
      
   2. time until peak flow greater than 120 ms;
      
   3. expiration time less than 2 s or volume accumulation has not dropped below 100 ml per 0.5 s.
      
   
   
3. exhalation time (forced expiratory time) less than 6 s.
   

Quality grading definitions used in EasyOne spirometer:

1. at least three acceptable tests AND the difference between the best two FEV and FVC values is equal to or less than 150 ml;
   
2. at least three acceptable tests AND the difference between the best two FEV and FVC values is equal to or less than 200 ml;
   
3. at least two acceptable tests AND the difference between the best two FEV and FVC values is equal to or less than 250 ml;
   
4. at least two acceptable trials but the results are not reproducible or only one acceptable trial;
   
5. no acceptable test available.
   

	ACKNOWLEDGMENTS

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 
The authors thank Professor P Mudge for comment on study design, and the doctors and staff in participating practices for their cooperation. The authors thank research nurses S Davoren and E Hammer for performing spirometry and calibration checks, Dr J Gartlan and Dr R Boland who assisted with extraction of data from practice records.

	FOOTNOTES

 
Funding: JAW was the recipient of a 2006 GlaxoSmithKline Australia postgraduate support grant.

Competing interests: None.

Ethical approval: The study protocol was approved by the Southern Health and Medical Human Research Ethics Committee.

Published Online First 5 December 2007

	REFERENCES

TOP ABSTRACT METHODS RESULTS DISCUSSION Appendix 1 Appendix 2 ACKNOWLEDGMENTS REFERENCES

 

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This Article Abstract Full Text (PDF) All Versions of this Article: thx.2007.082859v1 thx.2007.082859v2 63/5/408    most recent Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Google Scholar Articles by Walters, J A Articles by Wood-Baker, R PubMed PubMed Citation Articles by Walters, J A Articles by Wood-Baker, R Related Collections Related Article