Thorax

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER


[Advanced]
Thorax 2007;62:280; doi:10.1136/thx.2005.054700
Copyright © 2007 BMJ Publishing Group Ltd & British Thoracic Society
This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jayle, C P M
Right arrow Articles by Corbi, P J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jayle, C P M
Right arrow Articles by Corbi, P J
Topic Collections
Right arrow Thorax Images in Thorax

IMAGES IN THORAX

Left-ventricle leiomyosarcoma: imaging by multislices computed tomography with retrospective electrocardiogram-gated reconstruction

C P M Jayle1, L P Christiaens2, P Ardilouze3, S Franco4, P J Corbi5

1 Unité de chirurgie thoracique et cardiaque, Beauchant, CHU Poitiers, Poiters, France
2 Unité de cardiologie interventionnelle, Beauchant, CHU Poitiers, Poitiers, France
3 Pôle imagerie, Jean Bernard, CHU Poitiers, Poitiers, France
4 Unité de chirurgie thoracique et cardiaque, Beauchant, CHU Poitiers, Poiters, France
5 Unité de chirurgie thoracique et cardiaque, Beauchant, CHU Poitiers, Poiters, France

Correspondence to:
Correspondence to:
Dr C P M Jayle
Unités de Chirurgies thoracique et cardiaque, Beauchant, CHU Poitiers, Poitiers 86000, France;c.jayle{at}chu-poitiers.fr

A 49-year-old man was referred for dizziness and malaise. Echocardiogram showed a 3x2.5 cm mass within the left ventricle. A contrast-enhanced 16-row multislice computed tomography (MSCT) scan with retrospective ECG-gated reconstruction confirmed the mass, without infiltration of the left ventricular wall or marked coronary artery stenosis (fig 1Go). Surgical resection of the mass was performed, and 6 days later, the patient was discharged from hospital without radiotherapy or chemotherapy.


Figure 1
View larger version (91K):
[in this window]
[in a new window]
[PowerPoint for Teaching]
  		Figure 1  Sixteen slice computed tomographic imaging with retrospective electrocardiogram-gated reconstruction: subvalvular implantation of the tumour pediculated on the posterior papillary muscle, without infiltration of the left ventricular wall.

 
On pathological examination, the gross appearance was that of a soft, tan–yellow mass with smooth contours. Haemorrhagic areas were noted. The cells exhibited marked pleiomorphism and abundant mitotic figures. The tumour cells were positive for muscle cell antigen/CD34 and smooth muscle actin. Immunohistochemical stains were diffusely positive for vimentin and focally positive for desmin and CD68. These findings are consistent with the diagnosis of primary heart leiomyosarcoma.

After 18 months, a heart MSCT examination showed absence of recurrence of the tumour (fig 2Go). After 3 years, the patient is doing well with a normal echocardiogram and MSCT.


Figure 2
View larger version (35K):
[in this window]
[in a new window]
[PowerPoint for Teaching]
  		Figure 2  Sixteen slice computed tomographic imaging 18 months after the surgical treatment: absence of recurrence of the tumour.

 
Primary cardiac tumours are uncommon, with an incidence ranging from 0.001% to 0.03%.1 Leiomyosarcomas are about 9% of primary malignant cardiac tumours, and are highly aggressive and locally invasive. Leiomyosarcomas are uncommon malignancies of soft tissue associated with a poor prognosis owing to local and metastatic disease. Extra cardiac localisations are in the retroperitoneum, gastrointestinal tract, uterus, skin and vessels. Chemotherapy or radiotherapy gives poor results and are controversial.1,2 Surgical treatment offers the best chance of cure.


Learning points

  • Multislice computed tomography with retrospective echocardiogram-gated reconstruction provides an excellent anatomical definition of the cardiac tumour demonstrating the surgical resection possibilities.
  • Surgical treatment of cardiac tumours offers the best chance of cure, if it is possible and complete.

 

Echocardiograms are mainly used in the diagnosis of cardiac tumours. Our reported case illustrates the value of MSCT imaging in providing an excellent anatomical definition of the tumour, the screening of all cardiac chambers and the depiction of coronary artery vessels.


FOOTNOTES
Patient consent was not obtained for publication of details in this article.


References

  1. Butany J, Nair V, Naseemuddin A, et al. Cardiac tumours: diagnosis and management. Lancet Oncol 2005;6:219–28.[Medline]
  2. Centofanti P, Di Rosa E, Deorsola L, et al. Primary cardiac tumors: early and late results of surgical treatment in 91 patients. Ann Thorac Surg 1999;68:1236–41.[Abstract/Free Full Text]




This Article
Right arrow Extract Freely available
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this link to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Add article to my folders
Right arrow Download to citation manager
Right arrowRequest Permissions
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Jayle, C P M
Right arrow Articles by Corbi, P J
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jayle, C P M
Right arrow Articles by Corbi, P J
Topic Collections
Right arrow Thorax Images in Thorax

HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER
Terms and conditions relating to subscriptions purchased online  ¦  Website terms and conditions  ¦  Privacy policy
Copyright © 2007 BMJ Publishing Group Ltd & British Thoracic Society