EDITORIALS
Epithelial-mesenchymal transition: potential role in obliterative bronchiolitis?
1 Heart and Lung Institute, St Joseph’s Hospital and Medical Center, Phoenix, Arizona, USA
2 Department of Pediatrics, University of Arizona, Tucson, Arizona, USA
3 Division of Pulmonary and Critical Care Medicine, Will Rogers Institute Pulmonary Research Center, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Correspondence to:
Correspondence to Dr B C Willis, Heart and Lung Institute, 500 Thomas Rd, Suite 500, St Joseph’s Hospital and Medical Center, Phoenix, AZ 85260, USA; brigham.willis@chw.edu
| The first 150 words of the full text of this article appear below. |
Lung transplantation remains the only viable option for many patients suffering from a variety of progressive or intractable end-stage lung diseases. Despite significant advances in the prevention of early graft rejection, ischaemia-reperfusion injury and acute management of lung transplant recipients, significant challenges remain in the chronic management of patients after lung transplantation.1 In this issue of Thorax, Borthwick and colleagues2 provide intriguing new evidence that implicates the airway epithelium directly in the pathogenesis of bronchiolitis obliterans syndrome (BOS), the most significant factor in determining long-term lung graft survival (see page 770). As discussed in the study, the pathological lesion of BOS is obliterative bronchiolitis (OB), which recently has been postulated to be at least partially a disease of aberrant epithelial repair processes.3 Borthwick and colleagues provide evidence that epithelial to mesenchymal transition (EMT), a process whereby epithelial cells undergo a complete lineage transition to become fibroblasts and/or
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Thorax 2009 64: 770-777.[Abstract] [Full Text] [PDF]
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