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Lung function effects of chronic exposure to air pollution
Correspondence to:
Dr Jordi Sunyer, Center of Research of Environmental Epidemiology (CREAL), IMIM, Barcelona, Catalonia, Spain; jsunyer@creal.cat
| The first 150 words of the full text of this article appear below. |
Lung function is an excellent operative marker of the effects of air pollution in the general population. It is objective and quantitative, an early predictor of cardiorespiratory morbidity and mortality, able to describe trajectories to the occurrence of chronic obstructive pulmonary disease (COPD) and coherent with experimental data on deposition and accumulation of pollutants in airways and lungs and the resulting systemic inflammation and oxidative stress.1 2
Acute effects of air pollution are well established, whereas long-term effects are less certain. There is strong evidence of long-term effects of current levels of air pollution on lung function growth in children, resulting in deficits of lung function at the end of adolescence.3 However, there are no data about the potential reversibility of the deleterious effect afterwards. In adults, there is only one large long-term follow-up study.4 The strongest evidence for adverse long-term effects of air pollution on lung function in adults comes
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