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Thorax 2009;64:515; doi:10.1136/thx.2008.101006a
Copyright © 2009 BMJ Publishing Group Ltd & British Thoracic Society.

PULMONARY PUZZLE

ANSWER

The first 150 words of the full text of this article appear below.

From the question on page 483

Scar tissue has caused cicatricial supraglottic stenosis from histologically confirmed mucous membrane pemphigoid.

Dysphonia (from anterior glottic scarring) and dyspnoea (from posterior scarring) may progress to severe stenosis, stridor and life-threatening airway obstruction. Laryngeal stenosis predominantly affects children, either as a result of a congenital glottic web or papillomatosis. The subglottis is the most common site for a stricture secondary to an intubation injury. Inflammatory causes include croup, epiglottitis and laryngotracheobronchitis. Adult causes are shown in box 1.1


Box 1 Laryngeal obstruction or stenosis: aetiology and reported anatomical sites

Supraglottic

  • Carcinomas (95% squamous)
  • Relapsing polychondritis
  • Mucous membrane pemphigoid
  • Diphtheria
  • Epiglottitis

Transglottic

  • Carcinomas
  • Papillomatosis
  • Sarcoidosis
  • Tuberculosis
  • Perichondritis and radionecrosis
  • Fracture

Subglottic

  • Carcinomas
  • Wegener granulomatosis
  • Intubation injury

Other

  • Carcinoid, amyloid, Kaposi sarcoma, metastases, gastro-oesophageal reflux.


Mucous membrane pemphigoid is a rare chronic systemic autoimmune disease affecting the mucous membranes. Antibodies bind to the basement membrane causing subepidermal bullae which rupture with scarring. There is a preponderance of females and the sixth . . . [Full text of this article]


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Relevant Article

An unusual case of dyspnoea
E M Giddings, M V Holmes, D Lonsdale, J Rees, and M J Gleeson
Thorax 2009 64: 483. [Extract] [Full Text] [PDF]

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