EDITORIALS
The art of replication
Correspondence to:
Professor Michael Kabesch, Hannover Medical School, Center for Pediatrics, Clinic for Pneumology and Neonatology, Carl-Neuberg Strasse 1, D-30625 Hannover, Germany; Kabesch.Michael@mh.-hannover.de
| The first 150 words of the full text of this article appear below. |
Hot topics in science, like fashion, come and go. Asthma genetics is no exception to this rule. Asthma candidate genes come and very few stay for good, changing from "candidate" gene to "disease" gene. Only an exclusive few survive a thorough replication process.
The asthma candidate genes studied in the replication approach by Blakey and colleagues1 (pages 381–7) were originally discovered by positional cloning, a technique based on linkage studies using microsatellite markers and subsequent fine mapping of these linkage signal loci in families. Until recently, when genome-wide association studies (GWAS) entered the field, this was the method of choice to detect novel asthma candidate genes. In contrast to candidate gene studies, which are hypothesis driven and always only as good as the underlying hypothesis, positionally cloned genes had the aura of being the better asthma candidate genes, as they were detected by a systematic genomic approach not
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- Positionally cloned asthma susceptibility gene polymorphisms and disease risk in the British 1958 Birth Cohort
- J D Blakey, I Sayers, S M Ring, D P Strachan, and I P Hall
Thorax 2009 64: 381-387.[Abstract] [Full Text] [PDF]
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