Airwaves
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LUNG EPITHELIUM, RSV AND T CELLS
Respiratory viruses are important triggers of exacerbations of asthma and chronic obstructive pulmonary disease and interact with lung epithelial cells. Respiratory syncytial virus (RSV) infection is a key factor in the pathogenesis of asthma exacerbations. In this issue of Thorax, Wang and colleagues report important findings showing that healthy lung epithelial cells are potent inhibitors of T cell activation and proliferation and associated cytokine secretion. However, this regulatory function is lost or reduced depending on the severity of the RSV infection. In the accompanying editorial, Smyth provides a very clear account of airway epithelial function and describes the importance of the findings of Wang and colleagues and other researchers. She concludes, however, that "in health, the airway epithelium is like a duck—calm on the surface but paddling furiously underneath".
See pages 277and 283
TV IN CHILDHOOD CAUSES ASTHMA?
Environmental exposures associated with asthma have not been fully evaluated. Relationships have been described between
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