IMAGES IN THORAX

^99mTechnetium-labelled neutrophil scanning in pneumonia

P Ruparelia¹, K Szczepura², C Summers¹, A M Peters², E R Chilvers¹

¹ Department of Medicine, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, UK
² Department of Radiology, University of Cambridge School of Clinical Medicine, Addenbrooke’s and Papworth Hospitals, Cambridge, UK

Correspondence to:
Professor E R Chilvers, Respiratory Medicine Division, Department of Medicine, University of Cambridge School of Clinical Medicine, Box 157 Addenbrooke’s Hospital, Hill’s Road, Cambridge CB2 2QQ, UK; erc24@cam.ac.uk

The first 150 words of the full text of this article appear below.

A 70-year-old man with severe smoking-related chronic obstructive pulmonary disease (COPD) was recruited to a research study to examine the trafficking of 99m-technetium (^99mTc)-labelled neutrophils. These studies were undertaken in patients with stable moderate to severe COPD and designed to establish novel methodology (using autologous ^99mTc-labelled neutrophils and single photon emission computed tomography (SPECT)) to quantify neutrophil trafficking and accumulation within the lungs of patients with COPD. At the time of scanning he was clinically stable with a C-reactive protein of 6 mg/ml and peripheral neutrophil count of 3.2x10⁹/l. He was a current smoker with a >100 pack-year history and had no other lung condition. His last COPD exacerbation was 4 months before the scan.

He was injected with 200 MBq ^99mTc-labelled autologous neutrophils and underwent SPECT scanning at 45 min, 2 and 4 h post injection using a Picker Prism 2000 gamma camera. Following image . . . [Full text of this article]

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